1,5-Anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA

Article abstract of DOI:10.1080/07328319808004682

As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blocks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (d(h)U)₁₃/(dA)₁₃ duplex.

Full text of DOI:10.1080/07328319808004682

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1,5-Anhydro-2-Deoxy-D-Altritol
Oligonucleotides as Conformationally
Restricted Analogues of Rna
Brigitte Allart a , Arthur Van Aerschot a & Piet Herdewijn a
a Laboratory of Medicinal Chemistry , Rega Institute for Medical
Research, Katholieke Universiteit Leuven , Minderbroedersstraat 10,
B-3000, Leuven, Belgium
Published online: 22 Aug 2006.
To cite this article: Brigitte Allart , Arthur Van Aerschot & Piet Herdewijn (1998) 1,5-Anhydro-2-
Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna, Nucleosides and
Nucleotides, 17:9-11, 1523-1526, DOI: 10.1080/07328319808004682
To link to this article: http://dx.doi.org/10.1080/07328319808004682
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