Nucleosides, nucleotides and nucleic acids p. 507 - 517 (2003)
Update date:2022-07-30
Topics:
Izawa, Kunisuke
Takamatsu, Satoshi
Katayama, Satoshi
Hirose, Naoko
Kozai, Shigetaka
Maruyama, Tokumi
Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3′-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.
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