Synthesis of J-111,347, a novel 1β-methylcarbapenem with broad-spectrum antibacterial activity

DOI: 10.1248/cpb.48.310

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 310 - 311 (2000)

Update date:2022-08-04

Topics:

Authors:

Imamura, Hideaki

Ohtake, Norikazu

Sakuraba, Shunji

Shimizu, Aya

Yamada, Koji

Morishima, Hajime

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Article abstract of DOI:10.1248/cpb.48.310

Synthesis of J-111,347 (1), a new 1β-methylcarbapenem with broad- spectrum antibacterial activity including that against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, was achieved via diastereoselective preparation of a side-chain thiol 3 from an optically active (R)3,4-dihydroxybutanal 4.

Full text of DOI:10.1248/cpb.48.310

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