A Formylcarbonium Ion Synthon. Synthesis of 3-Thio-Substituted 2-Amino Acids and Thio-Substituted Enamines from 2-Acyloxyacrylonitriles

DOI: 10.1246/bcsj.60.609

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Bulletin of the Chemical Society of Japan p. 609 - 612 (1987)

Update date:2022-07-30

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Authors:

Oku, Akira

Hori-ie, Naofumi

Harada, Toshiro

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Article abstract of DOI:10.1246/bcsj.60.609

The utilization of 2-acyloxy-3-phenylthiopropionitriles (2) which were prepared by the Michael addition of thiophenol to 2-acyloxyacrylonitriles (CH2=C(CN)OCOR), as a formylcarbonium ion synthon, was demonstrated by the transformation of 2 into S-phenylcysteine and 2-phenylthio enamines.

Full text of DOI:10.1246/bcsj.60.609

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