Il Farmaco p. 77 - 82 (1999)
Update date:2022-07-30
Topics:
Albuquerque
Rocha Filho
Brandao
Lima
Ximenes
Galdino
Pitta
Chantegrel
Perrissin
Luu-Duc
Synthesis and physico-chemical properties of new 3-benzyl-4-thioxo-5-arylideneimidazolidine-2-ones and 3-benzyl-5-arylideneimidazolidine-2,4-dione are described. These compounds were synthesized by condensation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or 4-thioxoimidazolidine-2-ones. The N-alkylation of 5-benzylideneimidazolidine-2,4-dione led simultaneously to mono- and dialkylated derivatives. The nucleophilic addition of 1-methyl-3-benzylimidazolidine-2,4-dione with 2-cyano-3-(3,4-dichlorophenyl) acrylate also yielded the 3-substituted 5-arylideneimidazolidine-2,4-dione derivative. Antimicrobial in vitro activity was determined on some compounds.
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Doi:10.1016/S0040-4020(01)82810-6
(1969)Doi:10.1007/BF00943907
()Doi:10.1021/jm000922c
(2000)Doi:10.1021/jo00831a015
(1970)Doi:10.1016/S0957-4166(99)00095-6
(1999)Doi:10.1016/S0040-4039(99)02300-X
(2000)