Journal of Heterocyclic Chemistry p. 541 - 548 (1999)
Update date:2022-08-02
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Schnell, Barbara
The reaction of 4 with substituted diethyl malonates 5a, or 'magic malonates' (bis-2,4,6-trichlorophenylmalonates 5b) leads to 4-hydroxy-2(1H)- pyridones 6. The azomethines 4 are prepared via the Strecker compounds 3 starting with methyl ketones 1, anilines, and potassium cyanide. Chlorination of pyridones 6 with sulfuryl chloride leads to compounds 7 while nitration gives 9.
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Doi:10.1016/S0008-6215(00)82142-4
(1969)Doi:10.1007/BF01979253
(1996)Doi:10.1021/jo00830a088
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(1965)Doi:10.1021/om990269v
(1999)Doi:10.1055/s-1999-2690
(1999)
