Synthesis of 2'-α-C-allenyl-2'-deoxyuridine: An analogue of 2'-azido- 2'-deoxyuridine, known inhibitor of ribonucleotide diphosphate reductase (RDPR)

Article abstract of DOI:10.1016/S0040-4039(99)00917-X

The 1,2-propadienyl (allenyl) group was introduced by means of a radical reaction at the 2'-α- C position of uridine to prepare the rifle compound as a novel analogue of 2'-azido-2'-deoxyuridine, a known inhibitor of RDPR.