RSC Advances
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Schiff's bases with both primary and secondary amines under
Mannich reaction conditions. The reaction products were easily
isolated by ltration in very good to excellent yield and then
puried by recrystallization with the proper solvent. All the
synthesized products were used to remove Pb2+, Cd2+, Ca2+, and
Mg2+ from aqueous solution, with remarkable results. For
example, 70.27–93.92%, 72.29–92.40%, 70.95–92.00%, and
53.92–89.00% removal values were obtained for the removal of
8 K. S. Bhat, B. Poojary, D. J. Prasad, P. Naik and B. S. Holla,
Synthesis and antitumor activity studies of some new fused
1,2,4-triazole
derivatives
carrying
2,4-dichloro-5-
uorophenyl moiety, Eur. J. Med. Chem., 2009, 44(12),
5066–5070.
9 Y. A. Al-Soud, M. N. Al-Dweri and N. A. Al-Masoudi,
Synthesis, antitumor and antiviral properties of some 1,2,4-
triazole derivatives, Il Farmaco, 2004, 59(10), 775–783.
Mg2+, Pb2+, Cd2+, and Ca2+, respectively. Compound 10 exhibi- 10 I. Kuçukguzel, S. G. Kuçukguzel, S. Rollas, G. Otuk-Sanıs,
¨
¨ ¨
¨
¨
¨ ¨
¨
¨
ted the lowest values of removal at 21.06%, 7.41%, 9.09%, and
O. Ozdemir, I. Bayrak, T. Altug and J. P. Stables, Synthesis
30.00% for Pb2+, Cd2+, Ca2+, and Mg2+, respectively.
of some 3-(arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-
1,2,4-triazole derivatives and their anticonvulsant activity,
Il Farmaco, 2004, 59(11), 893–901.
Our synthesized compounds exhibited biological activity
against Escherichia coli, Pseudomonas aeruginosa, Bacillus sub-
tilis, Aspergillus niger, A. avus, and A. fumigatus. Therefore, 11 N. F. Eweiss, A. A. Bahajaj and E. A. Elsherbini, Synthesis of
these compounds have dual functions and can be used in water
remediation, and also for medical and pharmaceutical appli-
cations. In comparison with other materials reported in the
heterocycles. Part VI. Synthesis and antimicrobial activity of
some 4-amino-5-aryl-1,2,4-triazole-3-thiones and their
derivatives, J. Heterocycl. Chem., 1986, 23(5), 1451–1458.
literature, these adsorbents are highly competitive, as they have 12 J. M. Kane, M. W. Dudley, S. M. Sorensen and F. P. Miller,
high removal efficiencies and promising features for potential
applications. Further studies will focus on the adsorption
mechanism and the effect of other parameters on our synthe-
sized Mannich base compounds.
2,4-Dihydro-3H-1,2,4-triazole-3-thiones
antidepressant agents, J. Med. Chem., 1988, 31(6), 1253–
1258.
as
potential
13 M. Y. Mhasalkar, M. H. Shah, S. T. Nikam and C. V. Deliwala,
4-Alkyl-5-aryl-4H-1,2,4-triazole-3-thiols as hypoglycemic
agents, J. Med. Chem., 1970, 13(4), 672–674.
14 J. Liu, Q. Liu, X. Yang, Sh. Xu, H. Zhang, R. Bai, H. Yao,
J. Jiang, M. Shen, X. Wu and J. Xu, Design, synthesis, and
biological evaluation of 1,2,4-triazole bearing 5-substituted
Conflicts of interest
There are no conicts to declare.
biphenyl-2-sulfonamide
antihypertensive candidates, Bioorg. Med. Chem., 2013,
21(24), 7742–7751.
derivatives
as
potential
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