Synthesis of bicyclic proline analogs using a formal [3+2] intramolecular aziridine-allylsilane cycloaddition reaction

Article abstract of DOI:10.1016/S0040-4020(99)00425-1

Bicyclic proline analogs have a wide range of biological uses. We report here our synthesis of bicyclic proline analogs using a formal [3+2] intramolecular aziridine-allylsilane cycloaddition reaction. This synthesis allows for the preparation of both 5-5 and 6-5 fused ring systems and should be amenable to the preparation of analogs with substitution on the carbocyclic ring.