Facile Stereoselective Synthesis of (E)- and (Z)-α-Substituted Cinnamates by Stereoselective Dehydration Reaction with 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)

Article abstract of DOI:10.1016/S0040-4039(99)00923-5

Highly stereoselective syntheses of (E)- and (Z)-α-substituted cinnamates have been achieved by dehydration reaction of anti- and syn-α-substituted-β-hydroxyphenylpropionates with EDC in good yields. This facile method has been applied to the stereoselect