The Reaction of 1,2:3,4-Diepoxy-2,3-dimethylbutane with Nucleophiles

Article abstract of DOI:10.1002/hlca.19910740715

To find out whether the 1,4-addition to 1,2:3,4-diepoxides, which so far has been observed only once, is of a more general character, we investigated the reaction of a variety of O-, C-, N-, and S-nucleophiles with the model compound 1,2:3,4-diepoxy-2,3-dimethylbutane (Scheme 4).In several cases, 1,4-addition products could, indeed, be observed besides the expected 1,2-adducts (Table).