Nucleophilic substitution reaction of 3-acetyl-1-methoxyindole and its application for the synthesis of novel 2-substituted methyl 2,3-dihydro-1- methyl-3-oxo-5H-pyrido-[4,3-b]indole-4-carboxylates

DOI: 10.3987/COM-99-8608

Source and publish data:

Heterocycles p. 1949 - 1956 (1999)

Update date:2022-08-05

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Authors:

Somei, Masanori

Nakajou, Masahiro

Teramoto, Tsuyoshi

Tanimoto, Asuka

Yamada, Fumio

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Article abstract of DOI:10.3987/COM-99-8608

A simple synthetic route was established for 3-acetyl-1-methoxyindole, which was found to undergo nucleophilic substitution reactions selectively at the 2-position. Applying the reaction, novel 2-substituted methyl 2,3- dihydro-1-methyl-3-oxo-5H-pyrido[4,3-b]indole-4-carboxylates were prepared.

Full text of DOI:10.3987/COM-99-8608

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