Archiv der Pharmazie p. 709 - 715 (1992)
Update date:2022-08-02
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Phosphoramidic dichlorides 3 are synthesized by nucleophilic attack of methyl 2-(1-ethylenimino)-alkanoates 1 on POCl3 or by the reaction of amino acid methyl ester hydrochlorides 2 with POCl3. Subsequent treatment of 3 with ethylenimine affords the TEPA-analogs 4, and with 3-(1-ethylenimino)-1-propanol (6) the IFOSFAMID analogous 1,3,2-oxaza-phosphorines 5, the cytostatic activity of which was tested in the P388-leukemia of the CD2F1-mouse.
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Doi:10.1055/s-1999-2875
(1999)Doi:10.1039/a901521c
(1999)Doi:10.1107/S010827019900757X
(1999)Doi:10.1016/S0040-4039(99)01241-1
(1999)Doi:10.1021/jo000068x
(2000)Doi:10.1002/hlca.19800630848
(1980)
