Chemical and Pharmaceutical Bulletin p. 1314 - 1317 (1999)
Update date:2022-08-03
Topics:
Blanco, Jose M.
Caamano, Olga
Fernandez, Franco
Garcia-Mera, Xerardo
Hergueta, Antonio R.
Lopez, Carmen
Rodriguez-Borges, Jose E.
Balzarini, Jan
De Clercq, Eric
Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2- dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.
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