Synthesis and antiviral and antineoplastic activities of some novel carbocyclic guanosine analogues with a cyclobutane ring

DOI: 10.1248/cpb.47.1314

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1314 - 1317 (1999)

Update date:2022-08-03

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Authors:

Blanco, Jose M.

Caamano, Olga

Fernandez, Franco

Garcia-Mera, Xerardo

Hergueta, Antonio R.

Lopez, Carmen

Rodriguez-Borges, Jose E.

Balzarini, Jan

De Clercq, Eric

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Article abstract of DOI:10.1248/cpb.47.1314

Cyclobutyl nucleoside analogues containing guanine and 8-azaguanine (compounds 5-10) were prepared from (1R,cis)-3-aminomethyl-2,2- dimethylcyclobutylmethanol (1). All were evaluated as antiviral and antitumoral agents in a variety of assay systems. Compounds 6 and 7 showed a noteworthy activity against a respiratory syncytial virus and compound 10 was moderately active against vaccinia virus. Only compound 5 showed some cytostatic activity.

Full text of DOI:10.1248/cpb.47.1314

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