Tetrahedron p. 10325 - 10340 (1999)
Update date:2022-08-04
Topics:
Shibuya, Akira
Okada, Midori
Nakamura, Yuko
Kibashi, Mie
Horikawa, Hiroaki
Taguchi, Takeo
Preparation of methylenedifluorocyclopropanes 2 through the β- elimination reaction promoted by difluorocyclopropyl anion formed by cleavage of C-Si bond with TBAF is described. Base-catalyzed isomerization of 2 to difluorocyclopropene 11 shows the latter structure thermodynamically more stable in contrast to non-fluorinated cases. Application of this method to the synthesis of methylenedifluorocyclopropylglycine (F2MCPG) derivative 17 is also presented.
View MoreJiande City Silibase Silicone New Material Manufacture Co., Ltd.
Contact:15967177856
Address:Genglou Industrial Development Area
Shanghai Taibao Pharmaceutical Technology Co., Ltd(expird)
Contact:021-52217366
Address:shanghai
Wuhan Yitongtai Science and Technology Co.,Ltd.
Contact:+86-27-88933550
Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
website:http://www.win-winchemical.com
Contact:0086-577-64498589
Address:6F, No. 396 Xingping Road, Longwan Industrial Zone, Wenzhou City, Zhejiang, 325000 P.R.China
Contact:+86-519-86623222
Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Doi:10.1002/chem.201603449
(2016)Doi:10.1021/jo990772h
(1999)Doi:10.1021/jo00833a046
(1970)Doi:10.1016/S0040-4039(01)88677-9
(1969)Doi:10.1126/science.106.2743.91
(1947)Doi:10.1021/ol990830l
(1999)
