Tetrahedron p. 10325 - 10340 (1999)
Update date:2022-08-04
Topics:
Shibuya, Akira
Okada, Midori
Nakamura, Yuko
Kibashi, Mie
Horikawa, Hiroaki
Taguchi, Takeo
Preparation of methylenedifluorocyclopropanes 2 through the β- elimination reaction promoted by difluorocyclopropyl anion formed by cleavage of C-Si bond with TBAF is described. Base-catalyzed isomerization of 2 to difluorocyclopropene 11 shows the latter structure thermodynamically more stable in contrast to non-fluorinated cases. Application of this method to the synthesis of methylenedifluorocyclopropylglycine (F2MCPG) derivative 17 is also presented.
View MoreHAINAN JINYING IMPORT AND EXPORT CO. LTD
Contact:+86-898-32875423
Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Zouping Fuhai Technology Development Co., Ltd.
Contact:+0532-86934525 18660293207
Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Shanghai Bojing Chemical Co., Ltd.
Contact:021-37122233
Address:6F Buildiing 11,No.388,Baifu Road,District Fengxian.Shanghai, China.
HANGZHOU PANYU CHEMICAL CO.,LIMITED
Contact:+86-571-86578491
Address:Rm 605, NO.1870 Binsheng Road,Binjiang Dist, Hangzhou, China
Shandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Doi:10.1002/chem.201603449
(2016)Doi:10.1021/jo990772h
(1999)Doi:10.1021/jo00833a046
(1970)Doi:10.1016/S0040-4039(01)88677-9
(1969)Doi:10.1126/science.106.2743.91
(1947)Doi:10.1021/ol990830l
(1999)
