Synthesis, biological activity, and conformational analysis of four seco-D-15,19-bisnor-1α,25-dihydroxyvitamin D analogues, diastereomeric at C17 and C20

Article abstract of DOI:10.1021/jm980736v

The synthesis of four CD-ring-modified 19-nor-1α,25-dihydroxyvitamin D₃ derivatives lacking C15, referred to as 6C analogues, and diastereomeric at C17 and C20 is described. The synthesis involves an Ireland-Claisen rearrangement of a 3-methyl-