A general synthetic route towards bastadins. Part 1: Synthesis of the eastern part of bastadins 4-16

Article abstract of DOI:10.1016/S0040-4039(99)01429-X

A general synthetic route for the construction of the eastern part of the macrocyclic bastadins 4-16 is presented. The brominated biaryl ethers are synthesized using the iodonium salt method. The synthesis is accomplished within 18 steps in 15.5% overall