Journal of the Chinese Chemical Society p. 193 - 197 (1998)
Update date:2022-08-03
Topics: Regioselectivity Column chromatography NMR spectroscopy Steric hindrance Stirring TLC (thin-layer chromatography) Aromatic ring Nitration Workup Reaction Conditions Temperature Control Electrophilic Aromatic Substitution (EAS) Yield calculation Nitro group (–NO?)
Lin, Lee-Huey
Lin, Shaw-Tao
Yang, Huey-Ju
Gem-dihalocyclopropanes bearing a phenyl group and an additional group were nitrated by using nitric acid in a sulfuric acid matrix. The products from the nitration of aryl rings are major. The presence of a methyl group on the C(2) position of the cyclopropane ring leads to the isoxazoline from nitration at the C(1)-position instead of that from nitration at the C(2)-position.
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