Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties

DOI: 10.1248/cpb.47.1334

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Chemical and Pharmaceutical Bulletin p. 1334 - 1337 (1999)

Update date:2022-07-30

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Authors:

Fuji, Kaoru

Watanabe, Yukari

Ohtsubo, Tadamune

Nuruzzaman, Mohammad

Hamajima, Yoshio

Kohno, Michiaki

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Article abstract of DOI:10.1248/cpb.47.1334

Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.

Full text of DOI:10.1248/cpb.47.1334

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