An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

DOI: 10.1021/jo035264t

Source and publish data:

Journal of Organic Chemistry p. 192 - 194 (2004)

Update date:2022-07-30

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Authors:

Liu, Huaqing

Kerdesky, Francis A.

Black, Lawrence A.

Fitzgerald, Michael

Henry, Rodger

Esbenshade, Timothy A.

Hancock, Arthur A.

Bennani, Youssef L.

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Article abstract of DOI:10.1021/jo035264t

GT-2331 is a potent histamine H₃ antagonist which has entered clinical trials. Efficient multigram syntheses of this compound and its enantiomer are described. The literature reports that GT-2331 is the dextrorotatory (+), more potent, enantiom

Full text of DOI:10.1021/jo035264t

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