Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

Article abstract of DOI:10.1016/S0960-894X(98)00098-5

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P₂-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.