Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

DOI: 10.1016/S0960-894X(98)00098-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 687 - 690 (1998)

Update date:2022-08-04

Topics:

Authors:

Ghosh, Arun K.

Kincaid, John F.

Cho, Wonhwa

Walters, D. Eric

Krishnan

Hussain, Khaja Azhar

Koo, Yumee

Cho, Hanna

Rudall, Clare

Holland, Louis

Buthod, Jim

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Article abstract of DOI:10.1016/S0960-894X(98)00098-5

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P₂-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.

Full text of DOI:10.1016/S0960-894X(98)00098-5

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