The synthesis and anti-MRSA activity of amidinium-substituted 2-dibenzofuranylcarbapenems

DOI: 10.1016/S0960-894X(99)00526-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2973 - 2976 (1999)

Update date:2022-08-05

Topics:

Authors:

Laub, Joanne B.

Greenlee, Mark L.

DiNinno, Frank

Huber, Joann L.

Sundelof, Jon G.

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Article abstract of DOI:10.1016/S0960-894X(99)00526-0

A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a conseque

Full text of DOI:10.1016/S0960-894X(99)00526-0

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