Synthesis of (Rc,Ss)-1,1,1-trifluoro-3-(p-molylsulfinyl)-2-propanol by an asymmetric reduction with a yeast, Yamadazyma farinosa, as a key-step

Article abstract of DOI:10.1246/cl.1999.1255

(Rc,Ss)-1,1,1-trifluoro-3-(p-tolysulfinyl)-2-propanol (>99% e.e.), an important reagent for the asymmetric protonation of substituted enolates, was prepared (70%) from (S)-methyl p-tolyl sulfoxide. The stereoselectivity of the Yamdazyma farinosa-catalyzed