Synthesis of (-)-4-aza-4-deoxypodophyllotoxin from (-)-podophyllotoxin

DOI: 10.1016/S0040-4039(99)01932-2

Source and publish data:

Tetrahedron Letters p. 9107 - 9110 (1999)

Update date:2022-08-05

Topics:

Authors:

Hitotsuyanagi, Yukio

Kobayashi, Masatsugu

Morita, Hiroyuki

Itokawa, Hideji

Takeya, Koichi

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Article abstract of DOI:10.1016/S0040-4039(99)01932-2

(-)-4-Aza-4-deoxypodophyllotoxin (4) was synthesized from (-)-podophyllotoxin (1) through C-ring cleavage, Curtius rearrangement and intramolecular N-alkylation. Analogue 4 showed potent cytotoxicity against P388 leukemia cells.

Full text of DOI:10.1016/S0040-4039(99)01932-2

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