A versatile synthesis of tetraester polyamine lipids for gene transfection

DOI: 10.1016/S0040-4039(99)01934-6

Source and publish data:

Tetrahedron Letters p. 8985 - 8988 (1999)

Update date:2022-08-05

Topics:

Authors:

Lizarzaburu, Mike E.

Kurth, Mark J.

Nantz, Michael H.

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Article abstract of DOI:10.1016/S0040-4039(99)01934-6

The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis(p-methoxybenzyl)diether diol which was used to prepare the saturated and unsaturated diester cores.

Full text of DOI:10.1016/S0040-4039(99)01934-6

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