Tetrahedron Letters p. 8767 - 8770 (1999)
Update date:2022-08-04
Topics:
McCombie, Stuart W.
Lin, Sue-Ing
Vice, Susan F.
Aromatic and heterocyclic 2,2-dialkylhydrazides undergo directed metalation with 2 equivalents of n-, s- or t-BuLi, and the resulting C,N- dilithio species react with a variety of electrophiles. The products may be readily converted to the corresponding carboxylic acids or esters by oxidation with manganese dioxide in water or methanol containing acetic acid.
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Doi:10.1016/S0040-4039(99)01666-4
(1999)Doi:10.1016/S0040-4020(99)00957-6
(1999)Doi:10.1023/A:1022501815715
(2002)Doi:10.1021/ja982232s
(1999)Doi:10.1021/jm00296a027
(1970)Doi:10.1016/S0014-827X(99)00102-0
(1999)
