Bioorganic and Medicinal Chemistry Letters p. 1277 - 1279 (2000)
Update date:2022-07-30
Topics:
Upton, Christopher
Osborne, Richard H.
Jaffar, Mohammad
Potent H1-antagonistic activity in a series of novel indeno[2,1-c]pyridines and their 4-arylpiperidinol precursors is reported; one compound shows an in vitro activity four times that of the standard mepyramine that it was screened against. Their failure to translate this protection to in vivo tests is discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.
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