Certain 3,9-dideazapurines as inhibitors of purine nucleoside phosphorylase

Article abstract of DOI:10.1080/07328319908044619

The synthesis of four 3,9-dideazapurines is described. In order to achieve the desired substitution pattern, a new approach to the pyrrolo[2,3- c]pyridine ring system was devised utilizing the Gassman reaction as the key step for its construction. The four target heterocycles were all evaluated for their ability to inhibit human erythrocytic purine nucleoside phosphorylase.

Full text of DOI:10.1080/07328319908044619

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Nucleosides and Nucleotides
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Certain 3,9-Dideazapurines as Inhibitors
of Purine Nucleoside Phosphorylase
Jerry D. Rose a , John A. Secrist III a & John A. Montgomery a b
a Southern Research Institute , P.O. Box 55305, Birmingham, AL,
35255-5305
b BioCryst Pharmaceuticals, Inc. , 2190 Parkway Lake Drive,
Birmingham, AL, 35244
Published online: 04 Oct 2006.
To cite this article: Jerry D. Rose , John A. Secrist III & John A. Montgomery (1999) Certain 3,9-
Dideazapurines as Inhibitors of Purine Nucleoside Phosphorylase, Nucleosides and Nucleotides,
18:11-12, 2443-2461, DOI: 10.1080/07328319908044619
To link to this article: http://dx.doi.org/10.1080/07328319908044619
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