Bioorganic and Medicinal Chemistry Letters p. 3133 - 3136 (1998)
Update date:2022-09-26
Topics:
Smith III, Amos B.
Sasho, Setsuya
Barwis, Bari A.
Sprengeler, Paul
Barbosa, Joseph
Hirschmann, Ralph
Cooperman, Barry S.
A tetrahydropyran-based inhibitor (2) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized based on the heptapeptide, N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed that 2 is indeed a competent inhibitor, albeit less potent than 1.
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