Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by morphobase and chemproteobase profiling methods

DOI: 10.1021/acs.jmedchem.5b00035

Source and publish data:

Journal of Medicinal Chemistry p. 4230 - 4241 (2015)

Update date:2022-08-15

Topics:

Authors:

Minegishi, Hidemitsu

Futamura, Yushi

Fukashiro, Shinji

Muroi, Makoto

Kawatani, Makoto

Osada, Hiroyuki

Nakamura, Hiroyuki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/acs.jmedchem.5b00035

A series of indenopyrazoles was synthesized from the corresponding indanones and phenyl isothiocyanates in two steps. Among the compounds synthesized, methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate 6m (GN39482) was found to posse

Full text of DOI:10.1021/acs.jmedchem.5b00035

Products guided by the article

Product name:phenyl N-(3,5-dimethoxyphenyl) thiocarbamate

Cas No:279241-96-2

R&D Labs maybe for 279241-96-2

Nanjing Chemlin Chemical Co., Ltd.

website:http://www.echemlin.cn

Contact:+86-25-83697070

Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Jiangyin Tenghua Import&Export Co.,Ltd.

Contact:+86-510-86263875

Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Beijing Ribio Biotech Co.,Ltd

Contact:86-10-62664360

Address:Building 10,No.18 AnNingZhuang East Road, GuangHua Pioneer Park,HaiDian District, BeiJing China
Chemieliva Pharmaceutical Co., Ltd.

website:http://www.chemieliva.com

Contact:+86-23-67770219

Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang

Relevant to this article

The application of intramolecular radical cyclizations of acylsilanes in the regiospecific formation of cyclic silyl enol ethers

Doi:10.1021/jo010883s
(2001)
Reduction by a Model of NAD(P)H. 32. Stereoselective Reduction of Camphoroquinone by a Chiral NAD(P)H Model

Doi:10.1246/bcsj.54.3478
(1981)
Doi:10.1016/S0040-4039(01)98414-X
(1970)
An Efficient, Regiocontrolled Synthesis of 5-Aryl-2-carbethoxypyrroles from 3-Aryl-3-chloropropeniminium Salts

Doi:10.1021/jo00046a033
(1992)
Total synthesis of the lipoxygenase substrates (5Z,8Z,11Z,14Z)-nonadeca- 5,8,11,14-tetraene-1,19-dioic acid and (5Z,8Z,11Z,14Z)-20,20- dimethylheneicosa-5,8,11,14-tetraenoic acid

Doi:10.1055/s-2000-6400
(2000)
Acid-promoted homogeneous hydrogenation of alkenes catalyzed by the ruthenium-hydride complex (PCy₃)₂(CO)(Cl)RuH: Evidence for the formation of 14-electron species from the selective entrapment of the phosphine ligand

Doi:10.1021/om000315n
(2000)

Article Doi