A concise route to 3-hydroxy-4-methoxy-5-methylbenzaldehyde derivative

Article abstract of DOI:10.1080/00397910008086883

3-Hydroxy-4-methoxy-5-methylbenzaldehyde derivative (1c) has been synthesized in 7 steps from 2,3-dihydroxytoluene (4). An isopropyl derivative has been used to protect a phenol during this transformation. The overall yield of 1c was 37%.

Full text of DOI:10.1080/00397910008086883

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Concise Route to 3-
Hydroxy-4-Methoxy-5-
Methylbenzaldehyde Derivative
Naoki Saito a , Masashi Tachi a , Ryu-Ichi Seki a
,
Yayoi Sugawara a , Eri Takeuchi a & Akinori Kubo a
a Department of Pharmaceutical Sciences , Meiji
Pharmaceutical University , 2-522-1 Noshio, Kiyose,
Tokyo, 204-8588, Japan
Published online: 04 Dec 2007.
To cite this article: Naoki Saito , Masashi Tachi , Ryu-Ichi Seki , Yayoi Sugawara ,
Eri Takeuchi & Akinori Kubo (2000) A Concise Route to 3-Hydroxy-4-Methoxy-5-
Methylbenzaldehyde Derivative, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 30:13, 2407-2421, DOI:
10.1080/00397910008086883
To link to this article: http://dx.doi.org/10.1080/00397910008086883
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