Natural Product Research p. 682 - 688 (2016)
Update date:2022-08-03
Topics: Characterization Optimization Purification Data Analysis Structure-Activity Relationship (SAR) Analysis Design Synthesis of Starting Materials Amide Bond Formation Heterocycle Incorporation Antifungal Activity Evaluation
Wang, Xuesong
Gao, Sumei
Yang, Jian
Gao, Yang
Wang, Ling
Tang, Xiaorong
A series of heterocycle containing amide derivatives (1-28) were synthesised by the combination of acyl chlorides (1a, 2a) and heterocyclic/homocyclic ring containing amines, and their in vitro antifungal activity was evaluated against five plant pathogenic fungi, namely Gibberella zeae, Helminthosporium maydis, Rhizoctonia solani, Botrytis cinerea and Sclerotinia sclerotiorum. Results of antifungal activity analysis indicated that some of the products showed good to excellent antifungal activity, as compound 2 showed excellent activity against G. zeae and R. solani and potent activity against H. maydi, B. cinerea and S. sclerotiorum, and compounds 1, 8 and 10 also displayed excellent antifungal potential against H. maydi, B. cinerea and S. sclerotiorum and good activity against R. solani when compared with the standard carbendazim.
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