Journal of Medicinal Chemistry p. 3548 - 3571 (2015)
Update date:2022-08-15
Topics:
Haffner, Curt D.
Becherer, J. David
Boros, Eric E.
Cadilla, Rodolfo
Carpenter, Tiffany
Cowan, David
Deaton, David N.
Guo, Yu
Harrington, Wallace
Henke, Brad R.
Jeune, Michael R.
Kaldor, Istvan
Milliken, Naphtali
Petrov, Kim G.
Preugschat, Frank
Schulte, Christie
Shearer, Barry G.
Shearer, Todd
Smalley, Terrence L.
Stewart, Eugene L.
Stuart, J. Darren
Ulrich, John C.
A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in plasm
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