Use of 2-cyano-1-t-butylethyl or 2-cyano-1-(1,1-diethyl-3-butenyl)ethyl as a phosphorus protecting group in oligonucleotide synthesis via in situ phosphoramidite methods

Article abstract of DOI:10.1246/cl.2000.1134

2-Cyano-1-t-butylethyl or 2-cyano-1-(1,1-diethyl-3-butenyl)ethyl 3′-O-phosphorimidazolidite of 5′-O-protected nucleoside was prepared in situ by the use of 2-cyano-1-t-butylethyl or 2-cyano-1-(1,1-diethyl-3-butenyl)ethyl phosphorobisimidazolidite as a new