Enantioselective synthesis of the key intermediate of the acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitor (R-106578) using 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)2 as a catalyst

DOI: 10.1248/cpb.48.1567

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1567 - 1569 (2000)

Update date:2022-08-04

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Authors:

Murakami

Kobayashi

Hirai Hirai

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Article abstract of DOI:10.1248/cpb.48.1567

Acidic segment of an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, R-106578 was synthesized by enantioselective hydrogenation of the Z-olefine (9-(Z)) using (R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP)-Ru(OAc)₂ as a catalys

Full text of DOI:10.1248/cpb.48.1567

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