Bioorganic and Medicinal Chemistry Letters p. 2039 - 2042 (1999)
Update date:2022-09-26
Topics:
Matsuyama, Naoto
Kosaka, Tetsuya
Fukuhara, Mina
Soda, Yasuji
Mizuno, Koji
A series of polyunsaturated fatty acid anilides were synthesized and evaluated as ACAT inhibitors. Compound 24 had potent inhibitory activity against microsomal ACAT derived from U937, HepG2 and Caco-2 cell lines. Therefore, it might be expected to act as an antiarteriosclerotic and hypocholesterolemic agent. Interestingly, the ACAT inhibitory potency of 24 varied significantly depending on the source of the enzyme.
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