Uridylyl-(3′ → 5′)-(5′-thiouridine). An exceptionally base-labile diribonucleoside phosphate analogue

Article abstract of DOI:10.1016/0040-4039(95)00495-X

Like uridylyl-(3′→5′)-uridine (UpU), uridylyl-(3′→5′)-(5′-thiouridine) 2 both undergoes hydrolysis and isomerizes in aqueous acidic solution; however, it is very much more susceptible to hydrolysis than UpU under neutral and mildly basic conditions.