Dihydropyrazolopyrimidine Inhibitors of KV1.5 (IKur)

DOI: 10.1016/j.bmcl.2008.10.099

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6381 - 6385 (2008)

Update date:2022-08-03

Topics:

Authors:

Vaccaro, Wayne

Huynh, Tram

Lloyd, John

Atwal, Karnail

Finlay, Heather J.

Levesque, Paul

Conder, Mary Lee

Jenkins-West, Tonya

Shi, Hong

Sun, Lucy

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Article abstract of DOI:10.1016/j.bmcl.2008.10.099

A series of dihydropyrazolopyrimidine inhibitors of K_V1.5 (I_Kur) have been identified. The synthesis, structure-activity relationships and selectivity against several other ion channels are described.

Full text of DOI:10.1016/j.bmcl.2008.10.099

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Product name:1-[[7-(2,4-Dichlorophenyl)-4,7-dihydro-5-methyl-pyrazolo[1,5-a]pyrimidin-6-yl]carbonyl]-4-(4-fluoro-phenyl)piperazine

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