Journal of Medicinal Chemistry p. 620 - 624 (1980)
Update date:2022-08-02
Topics:
Leclerc, Gerard
Bieth, Nicole
Schwartz, Jean
New β-adrenergic blocking agents, most of which do not contain an aromatic nucleus, were synthesized.They were derived either from alkylamino-aliphatic oxime ethers, or alkylamino-aliphatic ethers.Most active among these are O-<3-(tert-butylamino)-2-hydroxypropyl>acetoxime (8; trachea pA2=7.65) and 1-isobutoxy-3-(tert-butylamino)-2-propanol (15, trachea pA2=7.49), both of which displayed bronchoselectivity (β2/β1 ratio ca. 15).The role and importance of the aromatic nucleus in this class of compounds are discussed
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