Synthesis of thiazole, triazole, pyrazolo[3,4-b]-pyridinyl-3-phenylthiourea, aminopyrazolo[3,4-b]pyridine derivatives and their biological evaluation

Article abstract of DOI:10.1080/10426500008082396

The pyrazolopyridine derivatives 1a,b reacted with phenylisothiocyanate (2), nitrous acid and cinnamonitrile derivatives 5a,b to afford the corresponded pyrazolo[3,4-b]-pyridinyl-3-phenylthiourea derivatives 3a,b, 3-diazotized aminopyrazolo[3,4-b]-pyridine derivatives 4a,b and Schiff bases 7a-d in a respective manner. Compounds 3a,b, 4a,b and 7a-d were taken as the starting materials for the present study owing to the presence of more than one active site. Compounds 3a,b reacted with the halogen-containing reagents e.g. 11a,b, 13 and 15 to give the corresponded thiazole derivatives 12a-d, 14a,b and 16a,b respectively. Compounds 4a,b coupled with the active hydrogen-containing reagents 17a-j to afford the corresponding 3-hydrazino derivatives 18a-t which could be cyclized to give the corresponding triazines 19a-t respectively. Compounds 7a-d reacted with thioglycolic acid (9) to give the corresponding thiazole derivative 10a-d in a good yield. The assigned structures of the newly synthesized compounds are based on their elemental analyses, 1R, ¹H NMR and mass spectra. The biological activity of some of these compounds was tested.

Full text of DOI:10.1080/10426500008082396

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Phosphorus, Sulfur, and
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Synthesis of Thiazole,
Triazole, Pyrazolo[3,4-b]-
Pyridinyl-3-Phenylthiourea,
Aminopyrazolo[3,4-
b]Pyridine Derivatives and
Their Biological Evaluation
Mohamed A.A. Elneairy a , Fawzy A. Attaby a &
Mohamed S. Elsayed a
a Chemistry Department Faculty of Science,
Cairo University, Giza, A. R., Egypt
Version of record first published: 03 Jan 2007.
To cite this article: Mohamed A.A. Elneairy , Fawzy A. Attaby & Mohamed S.
Elsayed (2000): Synthesis of Thiazole, Triazole, Pyrazolo[3,4-b]-Pyridinyl-3-
Phenylthiourea, Aminopyrazolo[3,4-b]Pyridine Derivatives and Their Biological
Evaluation, Phosphorus, Sulfur, and Silicon and the Related Elements, 167:1,
161-179
To link to this article: http://dx.doi.org/10.1080/10426500008082396
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