The Reactions of Acetals with Silyl Enol Ethers Promoted by the Combination of Tin(II) Chloride and Organic Halide. Novel and Convenient Synthesis of α,β-Unsaturated Ketones

Article abstract of DOI:10.1246/bcsj.63.3716

Acetals react with silyl enol ethers to give condensation products in good yield by the action of a reactive halide such as acetyl chloride or methoxymethyl chloride along with a catalytic amount of SnCl2.The procedure employing excessive amount of halide offers a novel and convenient method to synthesize conjugated enones.