Synthesis and preliminary pharmacological evaluation of analogues of caracasanamide, a hypotensive natural product

DOI: 10.1016/0960-894X(96)00079-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 653 - 658 (1996)

Update date:2022-07-30

Topics:

Authors:

Corelli, Federico

Dei, Donate

Delle Monache, Giuliano

Botta, Bruno

De Luca, Carlo

Carmignani, Marco

Volpe, Anna Rita

Botta, Maurizio

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Article abstract of DOI:10.1016/0960-894X(96)00079-0

Some analogues of the hypotensive agent caracasanamide have been synthesized and tested in vivo for cardiovascular effects. Derivative 2c emerged as the most interesting compound in the series. Structure-activity relationship is also discussed.

Full text of DOI:10.1016/0960-894X(96)00079-0

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