The functionalization of saturated hydrocarbons. Part 31. The Fe(pa)3 - and [Fe(tpa)Cl2]ClO4 - catalyzed oxidations of saturated hydrocarbons by hydrogen peroxide: A comparative mechanistic study

Article abstract of DOI:10.1016/0040-4020(95)00204-L

The Fe(pa)₃ and [Fe(tpa)Cl₂]ClO₄ catalyzed (pa = picolinic acid, tpa = tris(2-pyridylmethyl)amine) functionalization of saturated hydrocarbons by H₂O₂ in pyridine/acetic acid follows a common reaction pathway. Regioselectivity studies indicate, that a high valent iron species is responsible for the activation of the alkane. Alkyl hydroperoxides are the precursors for ketone and alcohol formation. Dioxygen provides the oxygen atoms in the alkyl hydroperoxide.