Bioorganic and Medicinal Chemistry Letters p. 2691 - 2696 (2001)
Update date:2022-08-05
Topics:
Barrow, James C
Nantermet, Philippe G
Selnick, Harold G
Glass, Kristen L
Ngo, Phung L
Young, Mary Beth
Pellicore, Janetta M
Breslin, Michael J
Hutchinson, John H
Freidinger, Roger M
Condra, Cindra
Karczewski, Jerzy
Bednar, Rodney A
Gaul, Stanley L
Stern, Andrew
Gould, Robert
Connolly, Thomas M
Thrombin is the most potent agonist of platelet activation, and its effects are predominantly mediated by platelet thrombin receptors. Therefore, antagonists of the thrombin receptor have potential utility for the treatment of thrombotic disorders. Screening of combinatorial libraries revealed 2 to be a potent antagonist of the thrombin receptor. Modifications of this structure produced 11k, which inhibits thrombin receptor stimulated secretion and aggregation of platelets.
View MoreShenyang Xingzhenghe Chemical Co., Ltd.
Contact:024-23509232
Address:No. 33, Naner Road, Heping Dist.
Changsha Goomoo Chemical Technology Co.Ltd
Contact:+86-731-82197655
Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Contact:86-0311-88310000
Address:Room 1109 Sunshine Plaza,No.46 Tang Gudun Road,Jianghan District Wuhan Hubei
website:http://www.joyochem.com
Contact:0531-82687998
Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China
Dezhou Longteng Chemical Co., Ltd.
website:http://www.sodium-methoxide.cn/
Contact:0086-18866052283
Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Doi:10.1016/S0008-6215(00)90386-0
(1986)Doi:10.1021/acs.joc.1c01090
(2021)Doi:10.1021/jo00952a042
(1973)Doi:10.3390/molecules23081859
(2018)Doi:10.1021/ol0167614
(2001)Doi:10.1039/c5cc04009d
(2015)