Angewandte Chemie - International Edition p. 10859 - 10863 (2020)
Update date:2022-08-05
Topics:
Gao, Yongyuan
Wu, Zhengguang
Yu, Lei
Wang, Yi
Pan, Yi
The C?O bond cleavage for activation of alcohols is synthetically useful and practically challenging. This work describes carbazate as a new type of electrochemically activated alkylating agent derived from ubiquitous alcohols for direct functionalization of heteroarenes under mild electrolytic conditions. The simple undivided cell at low oxidative potentials with carbon/platinum electrode set-ups offers excellent substrate tolerance, affording a variety of primary, secondary and tertiary alkyl-decorated heterocycles in good chemical yields. Furthermore, the mechanism for this electrochemical deoxyalkylation reaction has been investigated.
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