Nucleosides, nucleotides and nucleic acids p. 1305 - 1307 (2003)
Update date:2022-08-05
Topics: Deprotection Final steps Protection of 5'-hydroxyl group
Serebryany
Beigelman
1,2-Dideoxyribose 5-O-succinate, a component of solid support employed in the synthesis of ribozymes, was synthesized from thymidine. The key step was elimination of nucleobase from 2 to afford glycal 3. A number of catalysts for this reaction were tested
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