Journal of Organic Chemistry p. 1025 - 1033 (2015)
Update date:2022-08-05
Topics:
Feng, Xian
Wang, Jian-Jun
Xun, Zhan
Huang, Zhi-Bin
Shi, Da-Qing
A concise and efficient three-component domino reaction has been developed for the synthesis of polyfunctionalized indenopyridine and hydroisoquinoline derivatives via the cleavage of a C-C bond under transition-metal-free conditions. This reaction provides facile access to complex nitrogen-containing heterocycles by simply mixing three common starting materials in EtOH in the presence of 20 mol % NaOH under microwave irradiation conditions.
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