Synthesis of novel α-substituted and α,α-disubstituted amino acids by rearrangement of ammonium ylides generated from metal carbenoids

Article abstract of DOI:10.1021/ol017240j

(equation presented) A new and general four-step synthesis of protected a-substituted and α,α-disubstituted amino acids has been developed. The key step involves intramolecular ammonium ylide generation from a copper carbenoid with concomitant [2,3] rearr