Novel Erythromycin Derivatives with aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

DOI: 10.1021/jm0102349

Source and publish data:

Journal of Medicinal Chemistry p. 4137 - 4156 (2001)

Update date:2022-09-26

Topics:

Authors:

Zhenkun, Ma

Clark, Richard F.

Brazzale, Antony

Wang, Sanyi

Rupp, Michael J.

Li, Leping

Griesgraber, George

Zhang, Suoming

Yong, Hong

Phan, Tam Ly

Nemoto, Peter A.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm0102349

A novel series of erythromycin derivatives has been discovered with potent activity against key respiratory pathogens, including those resistant to erythromycin. These compounds are characterized by having an aryl group tethered to the C-6 position of the

Full text of DOI:10.1021/jm0102349

Products guided by the article

Product name:C₅₅H₁₀₄N₂O₁₄Si₂

Cas No:412333-77-8

R&D Labs maybe for 412333-77-8

Shanghai united Scientific Co.,Ltd.

Contact:+86-21-53535353

Address:28F No.900 huaihai Road Shanghai China
NEW FORTUNE INDUSTRIAL CO.,LTD.

website:http://newfortune.lookchem.com/

Contact:+86-25-8645-9456

Address:C4-105 GREEN ISLAND FLOWER TOWN
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.

Contact:15857995878 0579-82207761

Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,
Tianjin Pharmacn Medical Technology Co.,Ltd.

Contact:86-22-60122566ext.866(English),23359620

Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China

Relevant to this article

Doi:10.1021/ja01625a090
(1955)
Skimmiarepin A and B, Two New Insect Growth Inhibitory Triterpenoids from Skimmia japonica Thunb. var. intermedia Komatsu f. repens (Nakai) Hara

Doi:10.1246/bcsj.61.3225
(1988)
Studies with arylaminomethylbenzimidazolethiols: Novel synthesis of 1,3-diazepino- and 1,2,4-triazepino[1,2-a] benzimidazole derivatives

Doi:10.1080/10426509608046393
(1996)
Scope and selectivity of B(C₆F₅)₃-catalyzed reactions of the disilane (Ph₂SiH)₂

Doi:10.1016/j.jorganchem.2016.02.035
(2016)
Doi:10.1021/jo00964a028
(1973)
Tandem conjugate cyanide addition-Dieckmann condensation in the synthesis of the ABCD-ring system of lactonamycin.

Doi:10.1021/ol0257373
(2002)

Article Doi