Synthesis of [C2H3]methotrexate and [C2H3]7-hydroxymethotrexate

DOI: 10.1002/jlcr.537

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 29 - 36 (2002)

Update date:2022-08-05

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Authors:

Elmore, Charles S.

Dean, Dennis C.

Zhang, Yong

Gibson, Carter

Jenkins, Herb

Jones, Allen N.

Melillo, David G.

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Article abstract of DOI:10.1002/jlcr.537

Stable label analogues of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) were required for use as internal standards for LC/MS quantitation. A minimum incorporation of stable isotopes to produce a mass increase of 3 in the non-glutamate derived p

Full text of DOI:10.1002/jlcr.537

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